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Many Women with Early Stage Breast Cancer Experience Functional Decline After Initiating Treatment

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Embargo/Online Publication Date: 00:01 AM ET, Monday, June 27, 2016
[05.01 Hours UK Time (BST)/14:01 Hours Australian Eastern Standard Time (AEST), June 27]

NOTE: The information contained in this release is protected by copyright. Please include journal attribution in all coverage. A free abstract of this article will be available via the CANCER News Room upon online publication. For more information or to obtain a PDF of any study, please contact:


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In a study of older women with newly diagnosed stage I to III breast cancer, approximately one in five lost the ability to complete some of the basic tasks necessary for independent living within one year of initiating treatment. The study also found that a simple survey can help identify which women are at risk of such functional decline. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society.

A person’s functional status is a key measure of health. Previous research has shown that functional decline is associated with a decreased likelihood of recovery from a serious illness, an increased likelihood of dying, and a reduced ability to tolerate cancer treatment. Functional decline also results in a significant financial burden on individuals and society at large.

Because preventing functional decline could provide a number of benefits, it is important to identify which patients are most vulnerable. Cynthia Owusu, MD, MS, of Case Western Reserve University in Cleveland, and her colleagues attempted to do so in a group of 184 women aged 65 years and older who had been recently diagnosed with stage I to III breast cancer. The researchers used the Vulnerable Elders Survey, a 13-item self-administered tool that has been validated in community-dwelling elders to predict functional decline or death within 12 months. Patients completed the survey just prior to breast cancer treatment.

Within 12 months, 34 of the 184 patients developed functional decline and seven died. The risk of functional decline or death rose with increasing survey scores. Women without an education beyond high school were disproportionately affected.

“Our findings are important because the study validates the Vulnerable Elders Survey as a useful tool for identifying older women with breast cancer who may be at increased risk for functional decline within a year of treatment initiation. This instrument offers the opportunity for early identification and will inform the development of interventions to prevent and address functional decline for those particularly at risk, such as women with low socioeconomic status,” said Dr. Owusu. “Such efforts may in the long term translate to improved treatment tolerance and better breast cancer outcomes.”

Full Citation: “The Vulnerable Elders Survey and Socioeconomic Status Predict Functional Decline and Death among Older Women with Newly Diagnosed Non-metastatic Breast Cancer.” Cynthia Owusu, Seunghee Margevicius, Mark Schluchter, Siran M. Koroukian, Kathryn H. Schmitz, and Nathan A. Berger. CANCER; Published Online: June 27, 2016 (DOI: 10.1002/cncr.30046).

Author Contact: George Stamatis, University Hospitals Case Medical Center’s Sr. Media Relations Strategist, at or +1 216-844-3667.

About the Journal
CANCER is a peer-reviewed publication of the American Cancer Society integrating scientific information from worldwide sources for all oncologic specialties. The objective of CANCER is to provide an interdisciplinary forum for the exchange of information among oncologic disciplines concerned with the etiology, course, and treatment of human cancer. CANCER is published on behalf of the American Cancer Society by Wiley and can be accessed online at
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