Antiplatelet Therapy for Acute Coronary Syndromes

Release Date: September 1, 2016
Expiration Date: August 31, 2019

James A. de Lemos, MD
Sweetheart Ball-Kern Wildenthal, MD, PhD Distinguished Chair in Cardiology
Medical Director, Dallas Heart Study
University of Texas Southwestern
Dr. de Lemos has received consulting fees from Roche Diagnostics and a research grant from Abbott Diagnostics.

Target Audience
This continuing medical education activity is intended for physicians, surgeons and other members of the health care team. Most presentations will benefit primary care physicians in clinical practice. Office managers and administrators may also benefit from awareness and discussion of clinical initiatives and quality management issues.

Recorded slides and audio presentation. Resource materials may include downloads of videos, print materials, slides or web pages.

Learning Objectives
After participating in this activity participants will be able to:

  1. Recognize the difference between type 1 and type 2 myocardial infarction and the differences in management approaches between the two
  2. Appropriately select from among the available oral and intravenous P2Y12 inhibitors in clinical practice
  3. Perform individual assessment of risks and benefits of prolonged dual anti-platelet therapy in patients with ACS and those with intracoronary stents

Accreditation Statement


Case Western Reserve University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Case Western Reserve University School of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Planning Committee
Daniel Simon, MD, Activity Director
President, UH Harrington Heart & Vascular Institute
Chief, Division of Cardiovascular Medicine
UH Case Medical Center
Herman K. Hellerstein Chair in Cardiovascular Research and Professor of Medicine
Case Western Reserve University School of Medicine
Dr. Simon has received honoraria from Medtronic, and the CME Program has determined there is no conflict of interest. 

Sri Krishna Madan Mohan, MD
Chief Quality Officer
UH Harrington Heart & Vascular Institute
Assistant Professor of Medicine
Case Western Reserve University School of Medicine
Dr. Mohan reports no financial relationship with a commercial interest relevant to this activity. 

Trevor Jenkins, MD
Division of Cardiovascular Medicine
UH Case Medical Center
Assistant Professor of Medicine
Case Western Reserve University School of Medicine
Dr. Jenkins reports no financial relationship with a commercial interest relevant to this activity. 

Disclosure Statement
The policy of Case Western Reserve University School of Medicine CME Program (CWRU CME) requires that the Activity Director, planning committee members and all activity faculty (that is, anyone in a position to control the content of the educational activity) disclose to the activity participants all relevant financial relationships with commercial interests. Where disclosures have been made, conflicts of interest, real or apparent, must be resolved. Disclosure will be made to activity participants prior to the commencement of the activity. CWRU CME also requires that faculty make clinical recommendations based on the best available scientific evidence and that faculty identify any discussion of “off-label” or investigational use of pharmaceutical products or medical devices.

To receive a statement of credit for up to 1.0 AMA PRA Category 1 CreditTMyou must:

  1. Review and reflect on the full content of the recorded session.
  2. Successfully complete the post-test. A score of 75% is required for passage.
  3. Complete the evaluation.

Your credits will be recorded by the CWRU CME Program and made a part of your cumulative transcript. 

Estimated Time to Complete this Educational Activity
Including review of any resource material and completion of the post-test, this activity is expected to take 1 hour to complete.

There is no fee for this program.

To contact the CME Provider: Email CWRU CME at

Medical Disclaimer
Medicine is an ever-changing science. As new research and clinical experience broaden our knowledge, changes in treatment and drug therapy are required. The authors have checked with sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of publication.

Although every effort is made to ensure that this material is accurate and up-to-date, it is provided for the convenience of the user and should not be considered definitive.  Since medicine is an ever-changing science, neither the authors nor Case Western Reserve School of Medicine nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they are not responsible for any errors or omissions or for the results obtained from the use of such information. 

Readers are encouraged to confirm the information contained herein with other sources.  This information should not be construed as personal medical advice and is not intended to replace medical advice offered by physicians. Case Western Reserve University School of Medicine will not be liable for any direct, indirect, consequential, special, exemplary, or other damages arising therefrom. 

Thygesen et al. Universal Definition of Myocardial Infarction.
Circulation. 2012 Oct 16;126(16):2020-35. 

Wiviott SD. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2007
Nov 15;357(20):2001-15

Bonaca et al. Long-term use of ticagrelor in patients with prior myocardial infarction. N Engl J Med. 2015
May 7;372(19):1791-800.

Yeh, et al. Benefits and Risks of Extended Duration Dual Antiplatelet Therapy After PCI in Patients With and Without Acute Myocardial Infarction. J Am Coll Cardiol. 2015  May 26;65(20):2211-21.




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